Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals

Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals

In the presence of sodium, uric acid from purine metabolism precipitates as monosodium urate (MSU) needles and forms renal calculi or causes gouty arthritis in kidneys and joints, respectively. The latter is characterized by red, hot and swollen arthritic joints.Here we report the in vitro effect of...

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Bibliographic Details
Main Authors: Christine eSchorn, Christina eJanko, Veit eKrenn, Yi eZhao, Luis Enrique Munoz, Georg eSchett, Martin eHerrmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Immunology
Subjects:
Gout
Inflammation
MSU
ROS
opsonins
NETs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00376/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00376/full

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