DNA Double-Strand Breaks Induced in Human Cells by Twelve Metallic Species: Quantitative Inter-Comparisons and Influence of the ATM Protein

DNA Double-Strand Breaks Induced in Human Cells by Twelve Metallic Species: Quantitative Inter-Comparisons and Influence of the ATM Protein

Despite a considerable amount of data, the molecular and cellular bases of the toxicity due to metal exposure remain unknown. Recent mechanistic models from radiobiology have emerged, pointing out that the radiation-induced nucleo-shuttling of the ATM protein (RIANS) initiates the recognition and th...

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Bibliographic Details
Main Authors: Muriel Viau, Laurène Sonzogni, Mélanie L. Ferlazzo, Elise Berthel, Sandrine Pereira, Larry Bodgi, Adeline Granzotto, Clément Devic, Béatrice Fervers, Laurent Charlet, Nicolas Foray
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomolecules
Subjects:
metal toxicity
metal carcinogenesis
DNA double-strand breaks
ATM
Online Access:https://www.mdpi.com/2218-273X/11/10/1462

Internet

https://www.mdpi.com/2218-273X/11/10/1462

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