CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss

CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss

CD4+ T cells are typically considered as ‘helper’ or ‘regulatory’ populations that support and orchestrate the responses of other lymphocytes. However, they can also develop potent granzyme (Gzm)-mediated cytotoxic activity and CD4+ cytotoxic T cells (CTLs) have been amply documented both in humans...

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Bibliographic Details
Main Authors: Tom Hofland, Luca Danelli, Georgina Cornish, Tiziano Donnarumma, Deborah M. Hunt, Luiz P. S. de Carvalho, George Kassiotis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
CD4 T cell
granzyme B (GzmB)
immunological memory
TCF-1
mouse
human
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1168125/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1168125/full

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