Untargeted Metabolomics Showed Accumulation of One-Carbon Metabolites to Facilitate DNA Methylation during Extracellular Matrix Detachment of Cancer Cells

Untargeted Metabolomics Showed Accumulation of One-Carbon Metabolites to Facilitate DNA Methylation during Extracellular Matrix Detachment of Cancer Cells

Tumor cells detached from the extracellular matrix (ECM) undergo anoikis resistance and metabolic reprogramming to facilitate cancer cell survival and promote metastasis. During ECM detachment, cancer cells utilize genomic methylation to regulate transcriptional events. One-carbon (1C) metabolism is...

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Bibliographic Details
Main Authors: Suza Mohammad Nur, Mohammed Razeeth Shait Mohammed, Mazin A. Zamzami, Hani Choudhry, Aamir Ahmad, Bushra Ateeq, Irfan A. Rather, Mohammad Imran Khan
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Metabolites
Subjects:
one-carbon metabolism
ECM detachment
anoikis
DNA methylation
NKG2DLs
Online Access:https://www.mdpi.com/2218-1989/12/3/267

Internet

https://www.mdpi.com/2218-1989/12/3/267

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