Stage-specific and cell type-specific requirements of ikzf1 during haematopoietic differentiation in zebrafish

Abstract The zinc finger transcription factor Ikaros1 (Ikzf1) is required for lymphoid development in mammals. Four zinc fingers constitute its DNA binding domain and two zinc fingers are present in the C-terminal protein interaction module. We describe the phenotypes of zebrafish homozygous for two...

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Bibliographic Details
Main Authors: Isabell Hess, Sagar, Connor O´Meara, Dominic Grün, Michael Schorpp, Thomas Boehm
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25978-6