Tspan9 Induces EMT and Promotes Osteosarcoma Metastasis via Activating FAK-Ras-ERK1/2 Pathway

Tspan9 Induces EMT and Promotes Osteosarcoma Metastasis via Activating FAK-Ras-ERK1/2 Pathway

ObjectAt present, there are few effective treatment options available to patients suffering from osteosarcoma (OS). Clarifying the signaling pathways that govern OS oncogenesis may highlight novel approaches to treating this deadly form of cancer. Recent experimental evidence suggests that the trans...

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Bibliographic Details
Main Authors: Shijie Shao, Lianhua Piao, Jiangsong Wang, Liwei Guo, Jiawen Wang, Luhui Wang, Lei Tong, Xiaofeng Yuan, Xu Han, Sheng Fang, Junke Zhu, Yimin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Oncology
Subjects:
osteosarcoma
Tspan9
EMT
integrin β1
metastasis
FAK-Ras-ERK1/2 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.774988/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.774988/full

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