RAG2’s Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability

RAG2’s Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability

V(D)J recombination-associated DNA double-strand breaks (DSBs) are normally repaired by the high-fidelity classical nonhomologous end-joining (cNHEJ) machinery. Previous studies implicated the recombination-activating gene (RAG)/DNA postcleavage complex (PCC) in regulating pathway choice by preventi...

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Bibliographic Details
Main Authors: Marc A. Coussens, Rebecca L. Wendland, Ludovic Deriano, Cory R. Lindsay, Suzzette M. Arnal, David B. Roth
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713004038

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http://www.sciencedirect.com/science/article/pii/S2211124713004038

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