TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia

TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia

Microglia maintain brain homeostasis as the main immune cells in the central nervous system. Activation of sigma-1 receptor (Sig1R) plays neuroprotective and anti-inflammatory roles in microglia. Recent studies showed that Sig1R expression level has been reduced in the brain of the patients with neu...

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Bibliographic Details
Main Authors: Momoka Iwamoto, Yoki Nakamura, Masatoshi Takemura, Kazue Hisaoka-Nakashima, Norimitsu Morioka
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Histone deacetylase 6
Microglia
p38 mitogen-activated protein kinase
Sigma-1 receptor
Toll-like receptor 4
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300645

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http://www.sciencedirect.com/science/article/pii/S1347861320300645

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