Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues

Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues

DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers. Cold blooded vertebrates lack germinal centers, yet have a functional Ig gene mutator enzyme, Aicda. In fish there are clusters of Ai...

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Bibliographic Details
Main Authors: Doaa Waly, Aradana Muthupandian, Chia-Wei Fan, Harrison Anzinger, Brad G. Magor
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
antibody affinity maturation
VDJ repertoires
germinal center
evolution
somatic hypermutation
fish
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1058877/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1058877/full

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