Metabolic vulnerability of cancer stem cells and their niche

Metabolic vulnerability of cancer stem cells and their niche

Cancer stem cells (CSC) are the leading cause of the failure of anti-tumor treatments. These aggressive cancer cells are preserved and sustained by adjacent cells forming a specialized microenvironment, termed niche, among which tumor-associated macrophages (TAMs) are critical players. The cycle of...

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Bibliographic Details
Main Authors: Laura Marrone, Simona Romano, Chiara Malasomma, Valeria Di Giacomo, Andrea Cerullo, Rosetta Abate, Marialuisa Alessandra Vecchione, Deborah Fratantonio, Maria Fiammetta Romano
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
cancer stem cells
tumor dormancy
tumor associated macrophages
oxidative metabolism
anti-mitochondrial drugs in clinical trials
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1375993/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1375993/full

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