Metabolic vulnerability of cancer stem cells and their niche

Metabolic vulnerability of cancer stem cells and their niche

Cancer stem cells (CSC) are the leading cause of the failure of anti-tumor treatments. These aggressive cancer cells are preserved and sustained by adjacent cells forming a specialized microenvironment, termed niche, among which tumor-associated macrophages (TAMs) are critical players. The cycle of...

Full description

Bibliographic Details
Main Authors:	Laura Marrone, Simona Romano, Chiara Malasomma, Valeria Di Giacomo, Andrea Cerullo, Rosetta Abate, Marialuisa Alessandra Vecchione, Deborah Fratantonio, Maria Fiammetta Romano
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Series:	Frontiers in Pharmacology
Subjects:	cancer stem cells tumor dormancy tumor associated macrophages oxidative metabolism anti-mitochondrial drugs in clinical trials
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1375993/full

Similar Items

Tumor Dormancy: Implications for Invasion and Metastasis
by: Georgia Gomatou, et al.
Published: (2021-05-01)

Late Recurrence in Breast Cancer: To Run after the Oxen or to Try to Close the Barn?
by: Romano Demicheli, et al.
Published: (2021-04-01)

Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
by: Alberto Hernández-Barranco, et al.
Published: (2021-03-01)

The Role of the Innate Immune System in Cancer Dormancy and Relapse
by: Noah M. Chernosky, et al.
Published: (2021-11-01)

Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells
by: Scott Sauer, et al.
Published: (2021-04-01)

Does Physical Activity Have an Impact on Recurrence Dynamics in Early Breast Cancer Patients?
by: Elia Biganzoli, et al.
Published: (2021-02-01)

IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment
by: Amanda M. Clark, et al.
Published: (2021-05-01)

Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?
by: Nava Almog, et al.
Published: (2010-05-01)

Bioengineered models to study tumor dormancy
by: Shreyas S. Rao, et al.
Published: (2019-01-01)

Interpreting Breast Cancer Survival Data by the Hazard Function: Remarkable Findings from Event Dynamics
by: Romano Demicheli, et al.
Published: (2020-09-01)

Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer
by: Rana Jahanban-Esfahlan, et al.
Published: (2019-08-01)

Progress of research on the relationship between efferocytosis and tumor
by: Xuexin Yao, et al.
Published: (2024-04-01)

Regulation of Metastatic Tumor Dormancy and Emerging Opportunities for Therapeutic Intervention
by: Vasilia Tamamouna, et al.
Published: (2022-11-01)

Targeting Immune-Mediated Dormancy: A Promising Treatment of Cancer
by: Hao-fan Wang, et al.
Published: (2019-06-01)

The metastatic niche formation: focus on extracellular vesicle-mediated dialogue between lung cancer cells and the microenvironment
by: Francesca Pontis, et al.
Published: (2023-05-01)

Metabolic Features of Tumor Dormancy: Possible Therapeutic Strategies
by: Erica Pranzini, et al.
Published: (2022-01-01)

Principles of premetastatic niche formation
by: Yulia S. Korneva, et al.
Published: (2020-05-01)

Landscape and perspectives of macrophage -targeted cancer therapy in clinical trials
by: Shuhang Wang, et al.
Published: (2022-03-01)

Macrophage barrier in the tumor microenvironment and potential clinical applications
by: Shuai Ji, et al.
Published: (2024-01-01)

Bibliometric Analysis of Global Research on Tumor Dormancy
by: Yuzhe Zhang, et al.
Published: (2023-06-01)

Alterations of Cytoskeleton Networks in Cell Fate Determination and Cancer Development
by: Evan Ja-Yang Wang, et al.
Published: (2022-12-01)

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma
by: Lennart Lenk, et al.
Published: (2018-01-01)

Late Cutaneous Metastasis Originating from Gastric Cancer with Synchronous Metastasis
by: Ryota Koyama, et al.
Published: (2019-02-01)

Establishment and Application of in vitro and in vivo Model of Disseminated Tumor Cells with Dormancy
by: QUE Zujun, et al.
Published: (2023-11-01)

Mini-Review: Can the Metastatic Cascade Be Inhibited by Targeting CD147/EMMPRIN to Prevent Tumor Recurrence?
by: Michal A. Rahat, et al.
Published: (2022-03-01)

Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts
by: Eleonora Timperi, et al.
Published: (2023-06-01)

Role of Tumor-Associated Macrophages in Sarcomas
by: Tomohiro Fujiwara, et al.
Published: (2021-03-01)

The Role of Macrophages in Cancer Development and Therapy
by: Ewa Cendrowicz, et al.
Published: (2021-04-01)

Editorial: Macrophage immunity and metabolism in cancer: Novel diagnostic and therapeutic strategies
by: Jianmei W. Leavenworth, et al.
Published: (2022-12-01)

Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer
by: Yongmei Zhao, et al.
Published: (2022-08-01)

The Osteoclast Traces the Route to Bone Tumors and Metastases
by: Sharon Russo, et al.
Published: (2022-05-01)

Minimal residual disease in prostate cancer patients after primary treatment: theoretical considerations, evidence and possible use in clinical management
by: Nigel P. Murray
Published: (2018-09-01)

Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer
by: Rongze Olivia Lu, et al.
Published: (2021-01-01)

Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment
by: Zicong He, et al.
Published: (2021-09-01)

Metabolic Cancer-Macrophage Crosstalk in the Tumor Microenvironment
by: Kyra E. de Goede, et al.
Published: (2020-11-01)

Research Progress of Nano-drug Delivery System Targeting Tumor-associated Macrophage in Cancer Treatment
by: WANG Chenchen, et al.
Published: (2021-03-01)

Tumor-Associated Macrophages: Recent Insights and Therapies
by: Jiawei Zhou, et al.
Published: (2020-02-01)

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles
by: Jing Xie, et al.
Published: (2024-03-01)

Autophagy and Breast Cancer: Connected in Growth, Progression, and Therapy
by: Qitong Wu, et al.
Published: (2023-04-01)

An Evolutionary Explanation for the Perturbation of the Dynamics of Metastatic Tumors Induced by Surgery and Acute Inflammation
by: Alberto Carmona Bayonas
Published: (2011-03-01)