Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP<sup>res </sup>level disparity

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP<sup>res </sup>level disparity

<p>Abstract</p> <p>Background</p> <p>Prion disease transmission and pathogenesis are linked to misfolded, typically protease resistant (PrP<sup>res</sup>) conformers of the normal cellular prion protein (PrP<sup>C</sup>), with the former posited...

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Bibliographic Details
Main Authors: Lewis Victoria, Haigh Cathryn L, Masters Colin L, Hill Andrew F, Lawson Victoria A, Collins Steven J
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Molecular Neurodegeneration
Subjects:
Prion protein
Prion infectivity
Prion disease
Protease resistance
Subcellular localisation
Fractionation
Online Access:http://www.molecularneurodegeneration.com/content/7/1/18

Internet

http://www.molecularneurodegeneration.com/content/7/1/18

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