Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea

Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea

Mast cell (MC) activation triggered by immunoglobulin E (IgE)-antigen crosslinking involves intracellular Ca2+ influx through the ORAI1 channel, which precedes granule exteriorization and de novo synthesis of mediators. Pharmacologically suppressing MCs via the inhibition of the ORAI1 Ca2+ channel m...

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Bibliographic Details
Main Authors: Gyeongseo Suk, Do Hoon Kwon, Axel Roers, Soman N. Abraham, Hae Woong Choi
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Pharmacological Research
Subjects:
Mast cell
Allergy
ORAI1 inhibitor
Anaphylaxis
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823002438

Internet

http://www.sciencedirect.com/science/article/pii/S1043661823002438

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