Translating the Manufacture of Immunotherapeutic PLGA Nanoparticles from Lab to Industrial Scale: Process Transfer and In Vitro Testing

Translating the Manufacture of Immunotherapeutic PLGA Nanoparticles from Lab to Industrial Scale: Process Transfer and In Vitro Testing

Poly(lactic-co-glycolic acid) (PLGA) nanoparticle-based drug delivery systems are known to offer a plethora of potential therapeutic benefits. However, challenges related to large-scale manufacturing, such as the difficulty of reproducing complex formulations and high manufacturing costs, hinder the...

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Bibliographic Details
Main Authors: Maria Camilla Operti, Alexander Bernhardt, Jeanette Pots, Vladimir Sincari, Eliezer Jager, Silko Grimm, Andrea Engel, Anne Benedikt, Martin Hrubý, Ingrid Jolanda M. De Vries, Carl G. Figdor, Oya Tagit
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
drug delivery
PLGA
nanoparticles
nanomedicine
scale-up manufacturing
clinical translation
Online Access:https://www.mdpi.com/1999-4923/14/8/1690

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https://www.mdpi.com/1999-4923/14/8/1690

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