Liprin‐α1 contributes to oncogenic MAPK signaling by counteracting ERK activity

Liprin‐α1 contributes to oncogenic MAPK signaling by counteracting ERK activity

PTPRF interacting protein alpha 1 (PPFIA1) encodes for liprin‐α1, a member of the leukocyte common antigen–related protein tyrosine phosphatase (LAR‐RPTPs)‐interacting protein family. Liprin‐α1 localizes to adhesive and invasive structures in the periphery of cancer cells, where it modulates migrati...

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Bibliographic Details
Main Authors: Henna Pehkonen, Artemis Filippou, Juho Väänänen, Iida Lindfors, Mira Vänttinen, Philipp Ianevski, Anne Mäkelä, Pauliina Munne, Juha Klefström, Sanna Toppila‐Salmi, Reidar Grénman, Jaana Hagström, Antti A. Mäkitie, Piia‐Riitta Karhemo, Outi Monni
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Molecular Oncology
Subjects:
drug screen
head and neck squamous cell carcinoma
liprin‐α1
MEK/ERK inhibitor
MEK/ERK signaling pathway
RAS
Online Access:https://doi.org/10.1002/1878-0261.13593

Internet

https://doi.org/10.1002/1878-0261.13593

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