Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children

Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children

Background: Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya.Methods: We investigated the relationship between two novel complement component 5 (C5) missense muta...

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Bibliographic Details
Main Authors: Evans Raballah, Kristen Wilding, Samuel B. Anyona, Elly O. Munde, Ivy Hurwitz, Clinton O. Onyango, Cyrus Ayieko, Christophe G. Lambert, Kristan A. Schneider, Philip D. Seidenberg, Collins Ouma, Benjamin H. McMahon, Qiuying Cheng, Douglas J. Perkins
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
severe malarial anaemia
complement 5
missense mutations
P. facliparum
malaria
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.977810/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.977810/full

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