Chronic L-DOPA therapy alters central serotonergic function and L-DOPA-induced dopamine release in a region-dependent manner in a rat model of Parkinson's disease

Chronic L-DOPA therapy alters central serotonergic function and L-DOPA-induced dopamine release in a region-dependent manner in a rat model of Parkinson's disease

The therapeutic benefit of L-DOPA is commonly attributed to restoration of dopamine (DA) extracellular levels in the striatum of Parkinsonian patients. However, the loss of efficacy of L-DOPA after chronic use is paradoxically associated with a similar or enhanced striatal DA response. Release of L-...

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Bibliographic Details
Main Authors: Sylvia Navailles, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdère
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Chronic L-DOPA
Serotonin
Dopamine
Multi-site microdialysis
6-hydroxydopamine
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003827

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http://www.sciencedirect.com/science/article/pii/S0969996110003827

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