Surrogate Virus Neutralisation Test Based on Nanoluciferase-Tagged Antigens to Quantify Inhibitory Antibodies against SARS-CoV-2 and Characterise Omicron-Specific Reactivity in a Vaccination Cohort

Surrogate Virus Neutralisation Test Based on Nanoluciferase-Tagged Antigens to Quantify Inhibitory Antibodies against SARS-CoV-2 and Characterise Omicron-Specific Reactivity in a Vaccination Cohort

Virus-specific antibodies are crucial for protective immunity against SARS-CoV-2. Assessing functional antibodies through conventional or pseudotyped virus neutralisation tests (pVNT) requires high biosafety levels. Alternatively, the virus-free surrogate virus neutralisation test (sVNT) quantifies...

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Bibliographic Details
Main Authors: Michael Schoefbaenker, Rieke Neddermeyer, Theresa Guenther, Marlin M. Mueller, Marie-Luise Romberg, Nica Classen, Marc T. Hennies, Eike R. Hrincius, Stephan Ludwig, Joachim E. Kuehn, Eva U. Lorentzen
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Vaccines
Subjects:
SARS-CoV-2
Omicron BA.1
surrogate virus neutralisation test
pseudotyped virus neutralisation test
antibody quantification
nanoluciferase
Online Access:https://www.mdpi.com/2076-393X/11/12/1832

Internet

https://www.mdpi.com/2076-393X/11/12/1832

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