Self-Assembled TLR7/8 Agonist-Mannose Conjugate as An Effective Vaccine Adjuvant for SARS-CoV-2 RBD Trimer

Small synthetic TLR7/8-agonists can be used as vaccine adjuvants to enhance cell and humoral-mediated immune responses to specific antigens. Despite their potency, after local injection they can be dispersed to undesired body parts causing high reactogenicity, limiting their clinical applications. H...

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Bibliographic Details
Main Authors: Changcai Teng, Xiongyan Meng, Yeqin Hu, Hongzhao Mao, Huiting Li, Jing Yang, Tiantian Sun, Shuai Meng, Chengli Zong
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Polymers
Subjects:
Online Access:https://www.mdpi.com/2073-4360/14/24/5466