Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target

Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target

A feature of most neurodegenerative diseases is the presence of “mis-folded proteins” that form aggregates, suggesting suboptimal activity of neuronal molecular chaperones. Heat shock protein 90 (Hsp90) is the master regulator of cell responses to “proteotoxic” stresses. Some Hsp90 modulators activa...

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Bibliographic Details
Main Authors: Ranu Pal, Dongwei Hui, Heather Menchen, Huiping Zhao, Olivier Mozziconacci, Heather Wilkins, Brian S. J. Blagg, Christian Schöneich, Russell H. Swerdlow, Mary L. Michaelis, Elias K. Michaelis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Novobiocin analog
superoxide
mitochondria
complex I
pyruvate dehydrogenase kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1282855/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1282855/full

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