Predictive Biomarkers for Antipsychotic Treatment Response in Early Phase of Schizophrenia: Multi-Omic Measures Linking Subcortical Covariant Network, Transcriptomic Signatures, and Peripheral Epigenetics

Predictive Biomarkers for Antipsychotic Treatment Response in Early Phase of Schizophrenia: Multi-Omic Measures Linking Subcortical Covariant Network, Transcriptomic Signatures, and Peripheral Epigenetics

BackgroundVolumetric alterations of subcortical structures as predictors of antipsychotic treatment response have been previously corroborated, but less is known about whether their morphological covariance relates to treatment outcome and is driven by gene expression and epigenetic modifications.Me...

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Bibliographic Details
Main Authors: Xiaofen Zong, Changchun He, Xinyue Huang, Jinming Xiao, Lei Li, Meiling Li, Tao Yao, Maolin Hu, Zhongchun Liu, Xujun Duan, Junjie Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
schizophrenia
antipsychotic
subcortical covariant network
DNA methylation
MRI
Allen Human Brain Atlas
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.853186/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.853186/full

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