Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration

Abstract Background Intervertebral disc degeneration (IVDD) can cause low back pain, a major public health concern. IVDD is characterized with loss of cells especially those in nucleus pulposus (NP), due to the limited proliferative potential and regenerative ability. Few studies, however, have been...

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Bibliographic Details
Main Authors: Meng Xu, Junlan Huang, Min Jin, Wanling Jiang, Fengtao Luo, Qiaoyan Tan, Ruobin Zhang, Xiaoqing Luo, Liang Kuang, Dali Zhang, Sen Liang, Huabing Qi, Hangang Chen, Zhenhong Ni, Nan Su, Jing Yang, Xiaolan Du, Bo Chen, Chuxia Deng, Yangli Xie, Lin Chen
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Stem Cell Research & Therapy
Subjects:
Intervertebral disc degeneration
Nucleus pulposus
Cell proliferation
FGFR3
Genetic mouse models
Online Access:https://doi.org/10.1186/s13287-022-02903-2

Internet

https://doi.org/10.1186/s13287-022-02903-2

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