Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-c...

Full description

Bibliographic Details
Main Authors: Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu
Format: Article
Language:English
Published: Nature Portfolio 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07360-1

Internet

https://doi.org/10.1038/s41467-018-07360-1

Similar Items