Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation

Developmental cortical malformations are associated with a high incidence of drug-resistant epilepsy. The underlying epileptogenic mechanisms, however, are poorly understood. In rodents, cortical malformations can be modeled using neonatal freeze-lesion (FL), which has been shown to cause in vitro c...

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Bibliographic Details
Main Authors: Lauren Andresen, David Hampton, Amaro Taylor-Weiner, Lydie Morel, Yongjie Yang, Jamie Maguire, Chris G. Dulla
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002538