Magnetofection of miR-21 promoted by electromagnetic field and iron oxide nanoparticles via the p38 MAPK pathway contributes to osteogenesis and angiogenesis for intervertebral fusion

Magnetofection of miR-21 promoted by electromagnetic field and iron oxide nanoparticles via the p38 MAPK pathway contributes to osteogenesis and angiogenesis for intervertebral fusion

Abstract Background Magnetofection-mediated gene delivery shows great therapeutic potential through the regulation of the direction and degree of differentiation. Lumbar degenerative disc disease (DDD) is a serious global orthopaedic problem. However, even though intervertebral fusion is the gold st...

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Bibliographic Details
Main Authors: Tianqi Wang, Hongqi Zhao, Shaoze Jing, Yang Fan, Gaohong Sheng, Qing Ding, Chaoxu Liu, Hua Wu, Yang Liu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Nanobiotechnology
Subjects:
Bone tissue engineering
Electromagnetic field
Gene therapy
Iron oxide nanoparticles
Magnetofection
Online Access:https://doi.org/10.1186/s12951-023-01789-3

Internet

https://doi.org/10.1186/s12951-023-01789-3

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