A computational algorithm to assess the physiochemical determinants of T cell receptor dissociation kinetics

A computational algorithm to assess the physiochemical determinants of T cell receptor dissociation kinetics

The rational design of T Cell Receptors (TCRs) for immunotherapy has stagnated due to a limited understanding of the dynamic physiochemical features of the TCR that elicit an immunogenic response. The physiochemical features of the TCR-peptide major histocompatibility complex (pMHC) bond dictate bon...

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Bibliographic Details
Main Authors: Zachary A. Rollins, Jun Huang, Ilias Tagkopoulos, Roland Faller, Steven C. George
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
T cell receptor
Peptide major histocompatibility complex
Immunogenicity
Steered molecular dynamics
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022002616

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http://www.sciencedirect.com/science/article/pii/S2001037022002616

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