Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

Summary: Background: Immune checkpoint blockade (ICB) partially reverses the dysfunctional state of antigen-specific T cell in chronic infections. However, its impact on the diverse subsets of CD4+ T cells in humans is largely unknown. Methods: We examined immune checkpoint (IC) expression and func...

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Bibliographic Details
Main Authors: Elsa Brunet-Ratnasingham, Antigoni Morou, Mathieu Dubé, Julia Niessl, Amy E. Baxter, Olivier Tastet, Nathalie Brassard, Gloria Ortega-Delgado, Roxanne Charlebois, Gordon J. Freeman, Cécile Tremblay, Jean-Pierre Routy, Daniel E. Kaufmann
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:EBioMedicine
Subjects:
HIV-specific CD4+ T cells
T cell dysfunction
Immune checkpoint blockade
PD-1
TOX
CD4+ T cell subsets
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422004364

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http://www.sciencedirect.com/science/article/pii/S2352396422004364

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