Targeting AQP9 enhanced the anti-TNF therapy response in Crohn's disease by inhibiting LPA-hippo pathway

Although anti-TNF antibodies are extensively used to treat Crohn's disease (CD), a significant proportion of patients, up to 40%, exhibit an inadequate response to this therapy. Our objective was to identify potential targets that could improve the effectiveness of anti-TNF therapy in CD. Throu...

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Bibliographic Details
Main Authors: Minhao Yu, Yuan Shi, Yuan Gao, Yang Luo, Yihua Jin, Xiaoyi Liang, Zhuoran Tao, Guojun Zhu, Haiping Lin, Hao Li, Jun Qin, Zhijun Cao, Ming Zhong
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Pharmacological Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824001166