Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression

Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression

Malaria is a frequent parasitic infection becomes life threatening due to the disequilibrated immune responses of the host. Avid phagocytosis of malarial pigment hemozoin (HZ) and HZ-containing Plasmodium parasites incapacitates monocyte functions by bioactive lipoperoxidation products 4-hydroxynone...

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Bibliographic Details
Main Authors: Oleksii Skorokhod, Vincenzo Triglione, Valentina Barrera, Giovanna Di Nardo, Elena Valente, Daniela Ulliers, Evelin Schwarzer, Gianfranco Gilardi
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
malaria
human monocytes
lipoperoxidation
4-hydroxynonenal 4-HNE
hydroxyeicosatetraenoic acids HETEs
cytochrome P450
Online Access:https://www.mdpi.com/1422-0067/24/12/10232

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https://www.mdpi.com/1422-0067/24/12/10232

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