CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells

CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells

Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.

Bibliographic Details
Main Authors: Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02119-9

Internet

https://doi.org/10.1038/s42003-021-02119-9

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