Enantiomer‐Specific Cardiovascular Effects of the Ketone Body 3‐Hydroxybutyrate

Enantiomer‐Specific Cardiovascular Effects of the Ketone Body 3‐Hydroxybutyrate

Background The ketone body 3‐hydroxybutyrate (3‐OHB) increases cardiac output (CO) by 35% to 40% in healthy people and people with heart failure. The mechanisms underlying the effects of 3‐OHB on myocardial contractility and loading conditions as well as the cardiovascular effects of its enantiomeri...

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Bibliographic Details
Main Authors: Nigopan Gopalasingam, Niels Moeslund, Kristian Hylleberg Christensen, Kristoffer Berg‐Hansen, Jacob Seefeldt, Casper Homilius, Erik Nguyen Nielsen, Mie Ringgaard Dollerup, Aage K. Alstrup Olsen, Mogens Johannsen, Ebbe Boedtkjer, Niels Møller, Hans Eiskjær, Lars Christian Gormsen, Roni Nielsen, Henrik Wiggers
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
3‐hydroxybutyrate
heart failure
hemodynamics
ketone
metabolism
pressure‐volume loop
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.033628

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https://www.ahajournals.org/doi/10.1161/JAHA.123.033628

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