Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension

Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension

Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in multiple cell types, including vascular smooth mu...

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Bibliographic Details
Main Authors: Selina M. Garcia, Tracy R. Yellowhair, Neil D. Detweiler, Rosstin Ahmadian, Lindsay M. Herbert, Laura V. Gonzalez Bosc, Thomas C. Resta, Nikki L. Jernigan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
vascular remodeling
endothelium
proliferation
migration
right heart hypertrophy
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.989809/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.989809/full

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