CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development.

CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development.

Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness. Clarin 1, the protein product of CLRN1, is a four-transmembrane protein predicted to be associated with ribbon synapses of photoreceptors and cochlear hair cells, and...

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Bibliographic Details
Main Authors: Scott F Geller, Karen I Guerin, Meike Visel, Aaron Pham, Edwin S Lee, Amiel A Dror, Karen B Avraham, Toshinori Hayashi, Catherine A Ray, Thomas A Reh, Olivia Bermingham-McDonogh, William J Triffo, Shaowen Bao, Juha Isosomppi, Hanna Västinsalo, Eeva-Marja Sankila, John G Flannery
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2719914?pdf=render

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http://europepmc.org/articles/PMC2719914?pdf=render

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