Utilising polymorphisms to achieve allele-specific genome editing in zebrafish

Utilising polymorphisms to achieve allele-specific genome editing in zebrafish

The advent of genome editing has significantly altered genetic research, including research using the zebrafish model. To better understand the selectivity of the commonly used CRISPR/Cas9 system, we investigated single base pair mismatches in target sites and examined how they affect genome editing...

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Bibliographic Details
Main Authors: Samuel J. Capon, Gregory J. Baillie, Neil I. Bower, Jason A. da Silva, Scott Paterson, Benjamin M. Hogan, Cas Simons, Kelly A. Smith
Format: Article
Language:English
Published: The Company of Biologists 2017-01-01
Series:Biology Open
Subjects:
CRISPR/Cas9
Allele-specific
Zebrafish
Genome editing
Online Access:http://bio.biologists.org/content/6/1/125

Internet

http://bio.biologists.org/content/6/1/125

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