Bone Marrow Macrophages Induce Inflammation by Efferocytosis of Apoptotic Prostate Cancer Cells via HIF-1α Stabilization

Bone Marrow Macrophages Induce Inflammation by Efferocytosis of Apoptotic Prostate Cancer Cells via HIF-1α Stabilization

The clearance of apoptotic cancer cells by macrophages, known as efferocytosis, fuels the bone-metastatic growth of prostate cancer cells via pro-inflammatory and immunosuppressive processes. However, the exact molecular mechanisms remain unclear. In this study, single-cell transcriptomics of bone m...

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Bibliographic Details
Main Authors: Veronica Mendoza-Reinoso, Patricia M. Schnepp, Dah Youn Baek, John R. Rubin, Ernestina Schipani, Evan T. Keller, Laurie K. McCauley, Hernan Roca
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
hypoxia-inducible factor
efferocytosis
bone marrow macrophages
inflammation
Online Access:https://www.mdpi.com/2073-4409/11/23/3712

Internet

https://www.mdpi.com/2073-4409/11/23/3712

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