Simultaneously Targeting Two Coupled Signalling Molecules in the Mesenchymal Stem Cell Support Efficiently Sensitises the Multiple Myeloma Cell Line H929 to Bortezomib

Simultaneously Targeting Two Coupled Signalling Molecules in the Mesenchymal Stem Cell Support Efficiently Sensitises the Multiple Myeloma Cell Line H929 to Bortezomib

Several studies have shown that diverse components of the bone marrow (BM) microenvironment play a central role in the progression, pathophysiology, and drug resistance in multiple myeloma (MM). In particular, the dynamic interaction between BM mesenchymal stem cells (BM-MSC) and MM cells has shown...

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Bibliographic Details
Main Authors: P. M. Rojas-Zambrano, J. E. Meyer-Herrera, P. F. Ruiz-Aparicio, J. P. Vernot
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem/stromal cells
microenvironment
multiple myeloma
PKC
NF-κB
bortezomib
Online Access:https://www.mdpi.com/1422-0067/24/9/8157

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https://www.mdpi.com/1422-0067/24/9/8157

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