Exosomal miR-140-5p inhibits osteogenesis by targeting IGF1R and regulating the mTOR pathway in ossification of the posterior longitudinal ligament

Exosomal miR-140-5p inhibits osteogenesis by targeting IGF1R and regulating the mTOR pathway in ossification of the posterior longitudinal ligament

Abstract Background Ossification of the posterior longitudinal ligament (OPLL) is a disabling disease whose pathogenesis is still unclear, and there are no effective cures or prevention methods. Exosomal miRNA plays an important role in the osteogenesis of ectopic bone. Therefore, we focused on the...

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Bibliographic Details
Main Authors: Yifan Tang, Yanqing Sun, Junkai Zeng, Bo Yuan, Yin Zhao, Xiangwu Geng, Lianshun Jia, Shengyuan Zhou, Xiongsheng Chen
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Nanobiotechnology
Subjects:
OPLL
miR-140-5p
MSC
Exosome
Online Access:https://doi.org/10.1186/s12951-022-01655-8

Internet

https://doi.org/10.1186/s12951-022-01655-8

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