MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells

MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells

Progeroid syndromes (PS), including Hutchinson-Gilford Progeria Syndrome (HGPS), are premature and accelerated aging diseases, characterized by clinical features mimicking physiological aging. Most classical HGPS patients carry a de novo point mutation within exon 11 of the <i>LMNA</i> g...

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Bibliographic Details
Main Authors: Karim Harhouri, Pierre Cau, Frank Casey, Koffi Mawuse Guedenon, Yassamine Doubaj, Lionel Van Maldergem, Gerardo Mejia-Baltodano, Catherine Bartoli, Annachiara De Sandre-Giovannoli, Nicolas Lévy
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
progeria-like
MAD-B
progerin
prelamin A Δ90
prelamin A Δ35
MG132
Online Access:https://www.mdpi.com/2073-4409/11/4/610

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https://www.mdpi.com/2073-4409/11/4/610

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