Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the fusion of synaptic vesicles (SVs), whereas its role in the fusion of neuropeptide-containing dense core vesicles (DCV...

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Bibliographic Details
Main Authors: Aygul Subkhangulova, Miguel A Gonzalez-Lozano, Alexander JA Groffen, Jan RT van Weering, August B Smit, Ruud F Toonen, Matthijs Verhage
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
tomosyn
SNARE
secretion
neuropeptides
dense core vesicle
Online Access:https://elifesciences.org/articles/85561

Internet

https://elifesciences.org/articles/85561

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