MicroRNAs recruit eIF4E2 to repress translation of target mRNAs

Abstract MicroRNAs (miRNAs) recruit the RNA-induced silencing complex (RISC) to repress the translation of target mRNAs. While the 5′ 7-methylguanosine cap of target mRNAs has been well known to be important for miRNA repression, the underlying mechanism is not clear. Here we show that TNRC6A intera...

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Bibliographic Details
Main Authors: Shaohong Chen, Guangxia Gao
Format: Article
Language:English
Published: Oxford University Press 2017-07-01
Series:Protein & Cell
Subjects:
Online Access:http://link.springer.com/article/10.1007/s13238-017-0444-0