Emerging Structural Insights into Glycoprotein Quality Control Coupled with N-Glycan Processing in the Endoplasmic Reticulum

Emerging Structural Insights into Glycoprotein Quality Control Coupled with N-Glycan Processing in the Endoplasmic Reticulum

In the endoplasmic reticulum (ER), the sugar chain is initially introduced onto newly synthesized proteins as a triantennary tetradecasaccharide (Glc3Man9GlcNAc2). The attached oligosaccharide chain is subjected to stepwise trimming by the actions of specific glucosidases and mannosidases. In these...

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Bibliographic Details
Main Authors: Tadashi Satoh, Takumi Yamaguchi, Koichi Kato
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
calnexin/calreticulin cycle
cargo receptor
endoplasmic reticulum
intracellular lectin
N-glycan processing
NMR spectroscopy
glycoprotein quality control
X-ray crystallography
Online Access:http://www.mdpi.com/1420-3049/20/2/2475

Internet

http://www.mdpi.com/1420-3049/20/2/2475

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