Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors

Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors

The present study aims to discover novel derivatives as antiapoptotic agents and their protective effects against renal ischemia/reperfusion. Therefore, a series of new thiadiazole analogues <b>2a</b>–<b>g</b> was designed and synthesized through cyclization of the correspond...

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Bibliographic Details
Main Authors: Sara M. Mostafa, Ashraf A. Aly, Stefan Bräse, Martin Nieger, Sara Mohamed Naguib Abdelhafez, Walaa Yehia Abdelzaher, El-Shimaa M. N. Abdelhafez
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
hydrazinecarbothioamides
thiadiazoles
antiapoptotic activity
caspase-3
selectivity
histochemical staining
Online Access:https://www.mdpi.com/1420-3049/27/7/2266

Internet

https://www.mdpi.com/1420-3049/27/7/2266

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