Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer’s disease: a cerebrospinal fluid and fluorodeoxyglucose-positron emission tomography study

Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer’s disease: a cerebrospinal fluid and fluorodeoxyglucose-positron emission tomography study

Abstract Background Despite the high sensitivity of cerebrospinal fluid (CSF) amyloid beta (Aβ)42 to detect amyloid pathology, the Aβ42/Aβ40 ratio (amyR) better estimates amyloid load, with higher specificity for Alzheimer’s disease (AD). However, whether Aβ42 and amyR have different meanings and wh...

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Bibliographic Details
Main Authors: Caterina Motta, Martina Gaia Di Donna, Chiara Giuseppina Bonomi, Martina Assogna, Agostino Chiaravalloti, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cerebrospinal fluid biomarkers
Amyloid beta 40
Amyloid beta 42
Amyloid beta 42/40 ratio
Phosphorylated-tau
Online Access:https://doi.org/10.1186/s13195-023-01291-w

Internet

https://doi.org/10.1186/s13195-023-01291-w

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