PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread
Pulmonary carcinoid (PC) tumors are rare tumors that account for approximately 1% of all lung cancers. The primary treatment option is surgery, while there is no standard treatment for metastatic disease. As the number of PCs diagnosed yearly is increasing, there is a need to establish novel therape...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2019-08-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/8/8/EC-19-0308.xml |
| _version_ | 1819231573212397568 |
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| author | Tiina Vesterinen Teijo Kuopio Maarit Ahtiainen Aija Knuuttila Harri Mustonen Kaisa Salmenkivi Johanna Arola Caj Haglund |
| author_facet | Tiina Vesterinen Teijo Kuopio Maarit Ahtiainen Aija Knuuttila Harri Mustonen Kaisa Salmenkivi Johanna Arola Caj Haglund |
| author_sort | Tiina Vesterinen |
| collection | DOAJ |
| description | Pulmonary carcinoid (PC) tumors are rare tumors that account for approximately 1% of all lung cancers. The primary treatment option is surgery, while there is no standard treatment for metastatic disease. As the number of PCs diagnosed yearly is increasing, there is a need to establish novel therapeutic options. This study aimed to investigate programmed death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) expression in PC tumors since blocking of the PD-1/PD-L1 pathway is a promising therapeutic option in various other malignancies. A total of 168 PC patients treated between 1990 and 2013 were collected from the Finnish biobanks. After re-evaluation of the tumors, 131 (78%) were classified as typical carcinoid (TC) and 37 (22%) as atypic al carcinoid (AC) tumors. Primary tumor samples were immunohistochemically labeled for PD-1, PD-L1 and CD8. High PD-1 expression was detected in 16% of the tumors. PD-L1 expression was detected in 7% of TC tumors; all AC tumors were PD-L1 negative. PD-L1 expression was associated with mediastinal lymph-node metastasis at the time of diagnosis (P = 0.021) as well as overall metastatic potential of the tumor (P = 0.010). Neither PD-1 expression, PD-L1 expression nor CD8+ T cell density was associated with survival. In conclusion, PD-1 and PD-L1 were expressed in a small proportion of PC tumors and PD-L1 expression was associated with metastatic disease. Targeting of the PD-1/PD-L1 pathway with immune checkpoint inhibitors may thus offer a treatment option for a subset of PC patients. |
| first_indexed | 2024-12-23T11:47:06Z |
| format | Article |
| id | doaj.art-5b1ff3d49b504214a7d5c370ca7bc6d7 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-23T11:47:06Z |
| publishDate | 2019-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-5b1ff3d49b504214a7d5c370ca7bc6d72022-12-21T17:48:19ZengBioscientificaEndocrine Connections2049-36142049-36142019-08-018811681175https://doi.org/10.1530/EC-19-0308PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spreadTiina Vesterinen0Teijo Kuopio1Maarit Ahtiainen2Aija Knuuttila3Harri Mustonen4Kaisa Salmenkivi5Johanna Arola6Caj Haglund7HUSLAB, Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, FinlandDepartment of Biological and Environmental Science, University of Jyväskylä and Department of Pathology, Central Finland Health Care District, Jyväskylä, FinlandDepartment of Education and Research, Central Finland Central Hospital, Jyväskylä, FinlandDepartment of Pulmonary Medicine, Heart and Lung Center, and Cancer Center, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandHUSLAB, Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandHUSLAB, Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, FinlandPulmonary carcinoid (PC) tumors are rare tumors that account for approximately 1% of all lung cancers. The primary treatment option is surgery, while there is no standard treatment for metastatic disease. As the number of PCs diagnosed yearly is increasing, there is a need to establish novel therapeutic options. This study aimed to investigate programmed death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) expression in PC tumors since blocking of the PD-1/PD-L1 pathway is a promising therapeutic option in various other malignancies. A total of 168 PC patients treated between 1990 and 2013 were collected from the Finnish biobanks. After re-evaluation of the tumors, 131 (78%) were classified as typical carcinoid (TC) and 37 (22%) as atypic al carcinoid (AC) tumors. Primary tumor samples were immunohistochemically labeled for PD-1, PD-L1 and CD8. High PD-1 expression was detected in 16% of the tumors. PD-L1 expression was detected in 7% of TC tumors; all AC tumors were PD-L1 negative. PD-L1 expression was associated with mediastinal lymph-node metastasis at the time of diagnosis (P = 0.021) as well as overall metastatic potential of the tumor (P = 0.010). Neither PD-1 expression, PD-L1 expression nor CD8+ T cell density was associated with survival. In conclusion, PD-1 and PD-L1 were expressed in a small proportion of PC tumors and PD-L1 expression was associated with metastatic disease. Targeting of the PD-1/PD-L1 pathway with immune checkpoint inhibitors may thus offer a treatment option for a subset of PC patients.https://ec.bioscientifica.com/view/journals/ec/8/8/EC-19-0308.xmlneuroendocrine tumorpulmonary carcinoid tumorPD-1PD-L1immunohistochemistry |
| spellingShingle | Tiina Vesterinen Teijo Kuopio Maarit Ahtiainen Aija Knuuttila Harri Mustonen Kaisa Salmenkivi Johanna Arola Caj Haglund PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread Endocrine Connections neuroendocrine tumor pulmonary carcinoid tumor PD-1 PD-L1 immunohistochemistry |
| title | PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread |
| title_full | PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread |
| title_fullStr | PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread |
| title_full_unstemmed | PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread |
| title_short | PD-1 and PD-L1 expression in pulmonary carcinoid tumors and their association to tumor spread |
| title_sort | pd 1 and pd l1 expression in pulmonary carcinoid tumors and their association to tumor spread |
| topic | neuroendocrine tumor pulmonary carcinoid tumor PD-1 PD-L1 immunohistochemistry |
| url | https://ec.bioscientifica.com/view/journals/ec/8/8/EC-19-0308.xml |
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