Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy

Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy

Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus that eventually progresses to heart failure. The sarco(endo)plasmic reticulum calcium ATPase 2a (SERCA2a), an important calcium pump in cardiomyocytes, is closely related to myocardial systolic-diastolic function. In mammal...

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Bibliographic Details
Main Authors: Shuo Peng, Mengyi Wang, Shiwu Zhang, Ning Liu, Qianzhu Li, Jiaxin Kang, Lingxue Chen, Mingyu Li, Kemiao Pang, Jiayi Huang, Fanghao Lu, Dechao Zhao, Weihua Zhang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hydrogen sulfide
Diabetic cardiomyopathy
SERCA2a
SUMO1
SENPl
S-sulfhydration
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222201589X

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http://www.sciencedirect.com/science/article/pii/S075333222201589X

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