Munronoid I Ameliorates DSS-Induced Mouse Colitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Via Modulation of NLRP3

Munronoid I Ameliorates DSS-Induced Mouse Colitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Via Modulation of NLRP3

Inflammatory bowel diseases (IBDs) are increasingly common diseases characterized by chronic and relapsing inflammation of the gastrointestinal tract. NLRP3 might be a crucial regulator of the homeostatic balance of the intestine, but its upregulation leads to pyroptosis. Munronoid I is extracted an...

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Bibliographic Details
Main Authors: Xingyu Ma, Qianqian Di, Xiaoli Li, Xibao Zhao, Ruihan Zhang, Yue Xiao, Xunwei Li, Han Wu, Haimei Tang, Jiazheng Quan, Zherui Wu, Weilie Xiao, Weilin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel diseases
NLRP3: NOD-like receptor pyrin domain-containing protein 3
Munronoid I
pyroptosis
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.853194/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.853194/full

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