LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons

Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein). Dynein is the primary retrograde transport motor in axons, and m...

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Bibliographic Details
Main Authors: Jai P. Pandey, Liang Shi, Remi A. Brebion, Deanna S. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.841047/full