CYP27B1 Downregulation: A New Molecular Mechanism Regulating EZH2 in Ovarian Cancer Tumorigenicity

CYP27B1 Downregulation: A New Molecular Mechanism Regulating EZH2 in Ovarian Cancer Tumorigenicity

BackgroundOvarian cancer has the highest mortality rate among gynecologic cancers, and most patients are diagnosed in advanced stages. Enhancer of zeste homolog 2 (EZH2) is a major tumor marker and an effective therapeutic target for ovarian cancer, but the underlying molecular mechanism remains unc...

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Bibliographic Details
Main Authors: Xiao Huo, Hengzi Sun, Qiuhong Qian, Xiangwen Ma, Peng Peng, Mei Yu, Ying Zhang, Jiaxin Yang, Dongyan Cao, Ting Gui, Keng Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ovarian cancer
EZH2
ChIP-seq
steroid biosynthesis
CYP27B1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.561804/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.561804/full

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