Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

Abstract Background The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. The C9ORF72 expansion encodes five dipeptide repeat proteins (DPRs) that...

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Bibliographic Details
Main Authors: Nadja S. Andrade, Melina Ramic, Rustam Esanov, Wenjun Liu, Mathew J. Rybin, Gabriel Gaidosh, Abbas Abdallah, Samuel Del’Olio, Tyler C. Huff, Nancy T. Chee, Sadhana Anatha, Tania F. Gendron, Claes Wahlestedt, Yanbin Zhang, Michael Benatar, Christian Mueller, Zane Zeier
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
DNA damage
DNA double strand break repair
Induced pluripotent stem cells
CRISPR
Single-strand annealing
Online Access:http://link.springer.com/article/10.1186/s13024-020-00365-9

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http://link.springer.com/article/10.1186/s13024-020-00365-9

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