An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin 2 that associates with distinct treatment outcome...

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Bibliographic Details
Main Authors: Kenneth H. Gouin, Nathan Ing, Jasmine T. Plummer, Charles J. Rosser, Bassem Ben Cheikh, Catherine Oh, Stephanie S. Chen, Keith Syson Chan, Hideki Furuya, Warren G. Tourtellotte, Simon R. V. Knott, Dan Theodorescu
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25103-7

Internet

https://doi.org/10.1038/s41467-021-25103-7

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